HIV replication cycle in the host cell, antiretrovirals. In the upper left, HIV is fixed on a TCD4 lymphocyte seen in section, thanks to the CD4 receptor, fused using the co-receptor CCR5 and integrates the cell. Transcription of native viral RNA into proviral DNA (reverse transcriptase). Integration of proviral DNA into the genome of the host cell. Transcription of viral DNA into mRNA and synthesis of viral precursor proteins, assembly and budding release of new infecting viruses in the lower right.