Illustration of a hyper-segmented neutrophil (type of white blood cell, right) caused by WHIM (warts, hypogammaglobulinemia, immuPhotographydeficiency, myelokathexis) syndrome. WHIM syndrome is a rare genetic disease affecting the immune system. Patients have an abPhotographyrmally low number of neutrophils, and are less able to fight infection. WHIM syndrome is associated with a lack of neutrophils, but can also be associated with hyper-segmented neutrophils. This is where the nuclei in a patients neutrophils have 6 or more lobes, or a significant number have 5 or more. This can be a sign of several other diseases, however.