Pyoderma gangrenosum on a Hispanic male patient's abdomen that is being treated with the drug adalimumab (marketed under the name Humira). This disease causes painful ulcers on the skin. It is thought to be an autoimmune disorder, where the body's immune system attacks its own tissues. Treatment is with steroids and immunosuppressant drugs, although it can take many months for the ulcers to heal. Adalimumab is a human monoclonal antibody that targets excess tumour necrosis factor (TNF) in the body, overproduction of which causes inflammation, swelling, and pain.