Healing pyoderma gangrenosum lesion on the shoulder of a 22 year old Hispanic female patient who has been treated with infliximab for four weeks. Pyoderma gangrenosum causes painful ulcers on the skin. It is thought to be an autoimmune disorder, where the bodys immune system attacks its own tissues. Treatment is with steroids and immunosuppressant drugs, although it can take many months for the ulcer to heal. Infliximab is an immunosuppressant anti-inflammatory drug used to treat various diseases, including pyoderma gangrenosum.