Liver cirrhosis, illustration. The liver shows many small and large surface granules and is pale reddish and brownish in colour. The tissue has a hard almost board-like consistency. This is due to replacement of the normal highly cellular hepatocyte lobules with fibrous connective tissue forming septa among the remaining hepatocellular tissue or nodules. A common consequence of chronic and excessive alcohol consumption, cirrhosis may progress to end-stage liver disease. From Bollinger, O. 1901 Atlas und Gundriss der Pathologischen Anatomie, vol 1. Lehmann, Munich.