Epithelioid angiosarcoma of small bowel, light micrograph. Angiosarcoma is a rare, highly aggressive tumour that makes up less than 1% of all sarcomas. They show variable degrees of blood vessel formation and range from well-differentiated tumours resembling haemangiomas to highly anaplastic solid tumour that may be mistaken for poorly-differentiated carcinomas or sarcomas. The most common location is skin (scalp, face, forehead, and neck), followed by parenchymal organs (breast, heart, liver, spleen, and bone) and deep soft tissues. The peak incidence is seen in the 7th decade. This image shows epithelioid angiosarcoma that involved the small bowel. The tumour is composed of plump epithelioid cells with highly atypical nuclei and abundant eosinophilic cytoplasm. Epithelioid angiosarcomas are often mistaken for poorly-differentiated carcinomas, melanomas, or other high-grade sarcomas.