Meditation modifies the way the brain works, activating areas of the brain involved in pain control. Mindfulness meditation modifies the relationship to pain. The main difference has been found in the posterior cingulate, which is involved in concentration and self-awareness. The insular or insula cortex is associated with limbal functions, behaviours and emotions and the formation of memory, its anterior part is involved in anticipating pain and some regions of the prefrontal cortex. The placebo effect triggers the production of molecules with pain-relieving effects, comparable to those that a real drug would have produced. The psychological suggestion causes biochemical consequences, with activity in an area of the brain called the accumbens nucleus.