Brain and spine in situ, lumbar nociceptors, nerve impulses, treatment. Anatomical situation of lumbago on a silhouette. On the left, details of the path of nerve impulses from nociceptors located at the level of the vertebral cartilages (magnifying glass), intervertebral disc, anterior longitudinal ligament, supraspinous ligament or interspinous ligaments. From there he climbs to the brain through the posterior horn of the spinal cord. The magnifying glass shows cartilage cells producing cyclooxygenase (COX) promoting the synthesis of prostaglandins E2 mediating inflammation and pain as well as A2 thromboxanes.