ARNT-HIF complex with hypoxia response element, illustration. Hypoxia-inducible factor complex (HIF, pink) and aryl hydrocarbon receptor nuclear translocator (ARNT, purple) are forming a complex with hypoxia response element (HRE). The HRE takes the form of a short sequence of DNA (helical, yellow). Hypoxia-inducible factors (HIFs) coordinate cellular adaptations to low oxygen stress in metabolic processes such as erythropoiesis and angiogenesis.

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