Piero Capponi (1447 - September 25; 1496) was an Italian statesman and warrior from Florence.

He was at first intended for a business career; but Lorenzo de' Medici; appreciating his ability; sent him as ambassador to various courts; where he acquitted himself with distinction.

On the death of Lorenzo (1492); who was succeeded by his son; the weak and incapable Piero; Capponi became one of the leaders of the anti-Medicean faction which two years later succeeded in expelling Piero de' Medici from Florence. Capponi was then made chief of the republic and conducted public affairs with great skill; notably in the difficult negotiations with Charles VIII of France; who had invaded Italy in 1494 and in whose camp the exiled Medici had taken refuge.