Comfrey. 16th century Italian illustration of a comfrey plant (Symphytum bulbosum), by Gherardo Cibo, 1568. Comfrey was used in traditional medicine to treat wounds, broken bones and bronchial problems. This plate is taken from Discorsi on Dioscorides' De Materia Medica by Pietro Andrea Mattioli, a work of herbal medicine first published in Italy in 1554. Pietro Andrea Mattioli (1501-1577) was an Italian doctor and naturalist who wrote commentaries on De Materia Medica , an encyclopaedia of herbal medicine by the first century Greek physician and botanist Dioscorides.