Hormone replacement therapy (HRT) for the treatment and prevention of post-menopausal osteoporosis. Here, a doctor is about to implant a pellet containing oestradiol, a female sex hormone, under the skin of a woman's abdomen. In osteoporosis, a reduction in bone density leads to an increase of fractures following minimal trauma, particularly in the neck of the femur (upper thigh), the vertebrae (which collapse) & the forearm. Bone loss increases following the menopause. Oestrogen replacement (ie HRT) is the only therapy which has been demonstrated to prevent osteoporosis & reduce the number of related fractures. Name of hormone pellet is Organone""