Model released. Pancreatic enzyme replacement in cystic fibrosis. A dietician showing pancreatic enzyme pills to a young cystic fibrosis patient. Cystic fibrosis is a hereditary disease which affects the exocrine glands. One effect of this is the lowering of production of the pancreatic enzymes that are vital to digestion and the absorption of fats. The use of pancreatic enzyme pills depends on the individual patient and their diet. Many children prefer to take the content of the pills rather than swallowing them whole. Other effects of the disease include obstruction of the intestine and bronchi by mucus.