Action of designed enediynes: Last of 4 molecular graphics showing the cleavage of DNA by a synthetic enediyne (at top). A number of these compounds have been designed by K.C. Nicolaou & colleagues at the Scripps Research Institute, California, to mimic the selective anticancer properties of more complex naturally- occurring relatives. The enediynes are designed with functional groups that target the DNA & trigger a series of reactions that result in its breakage. The DNA model was produced by J.Macke for a video by M.Pique entitled ENEDIYNES: CHEMICAL WARFARE AGAINST CANCER.