Madonna and Child Enthroned with St John Baptist, St Francis, St Jerome, St Sebastian (Pala Buffi), by Giovanni Santi, 1489 about, 15th Century, painting on curved panel, cm 330 x 221. Italy, Marche, Pesaro Urbino, Urbino, Marche National Gallery. The painting is known as Pala Buffi from the Urbinate name of the family that commissioned it for the altar of the chapel of San Sebastiano in the church of San Francesco. The entire composition symbolize a great ex-voto. Detail. Commissioners man woman baby child cap bonnet family floor marble anatomy body wounds arrows St Sebastian red green blue.